March 17, 2020 at 10:18 am #343794
If you notice someone coughing or sneezing, leave behind you a mask as you distant yourself immediately. It is nice and responsible of you to offer masks to people who are symptomatic. Thing is anyone who is symptomatic is supposed to self quarantine themselves and not be present in any social situation.
What I understand about this virus is that it is of the common cold type virus. The common cold virus mutates a whole lot, and that is why there is no vaccine for it. If I suffer from the common cold 8 times per year, for example, each time it is a different virus. The Coronavirus is of the common cold type and it is feared that it will mutate. So far, according to Wikipedia yesterday, “More than 7,000 people have died from the disease and over 78,000 have recovered”-
So less than 1% of the people infected with the virus died, and more than 99% of the people infected recovered. A way greater percentage of people infected with influenza die from it every year. So what is the great emergency, one may ask. The emergency is, as I understand it, that the influenza virus is relatively stable, doesn’t mutate spontaneously and quickly like the common cold virus, so 100 people with influenza are suffering from the same virus, and therefore they will react well to one medication (and one vaccine will prevent influenza in most people). But the Coronavirus, it is feared that it will mutate into more aggressive forms that will claim way more than 1% of the lives of infected people, perhaps 25%,or 50%, or 75%, I don’t know. I don’t think anyone knows.
The idea behind social distancing is to prevent people from being infected with the current milder form of Coronavirus before it mutates. Scary stuff.
anitaMarch 17, 2020 at 10:54 am #343798
Exactly this is why I am so motivated to get into research. All hands on deck. And I would be better off spending my time preparing myself for research then sewing masks. I think I am finally calm enough to go to the grocery store.
Thank you for helping me not be so hard on myself and take proper steps to help.March 17, 2020 at 11:03 am #343800
You are welcome. I am thinking about starting a thread on the Coronavirus, and I hope you can help me with the scientific understanding of the virus, in that thread.
anitaMarch 17, 2020 at 11:27 am #343808
What a wonderful idea. I will help the best I can. Maybe one thread for safety measures and one thread for updated research ? I am trying to think how we would organize the information.
I just thought of something. History on Repeat Ending= H.O.P.EMarch 17, 2020 at 11:32 am #343812
“History on Repeat Ending= H.O.P.E”- HORE it would be, close. How is that relating to the new thread?
anitaMarch 17, 2020 at 12:03 pm #343814
I think I need to sleep more by brain isn’t all with it. I’m sorry. I’ll be back soon.
ZeezaMarch 17, 2020 at 1:14 pm #343820
No need to apologize. My brain isn’t all with it either, I just spent a long time reading and writing about viruses in general and I lost all that I put together because I failed to copy it. Take your time. I hope you rest!
anitaMarch 18, 2020 at 2:31 pm #343986
A promoter is a part of a gene that can turn on or off a gene. It is like a light switch being turned on or off.
Turning a gene on or off means turning on or off synthesis of various proteins.
The promoter is like a binding site. When a Transcription Factor (protein) meets the binding site, the promoter is turned on, and thus the gene is turned on to do transcription. RNA Polymerase is an enzyme that helps this process. Transcription is turning DNA(genetic instructions) to make messenger RNA (mRNA).
Another way to look at transcription is as if you were following a cooking recipe that wasn’t available to you before but it is now! Now the DNA has new instructions for protein synthesis.
The next step after Transcription is Translation. Translation is when mRNA is read by tRNA. This process gets help from a friend to make this new recipe. This friend is called rRNA.
The first human vaccine trial has occurred in Seattle. A vaccine is usually a way to introduce a “weak” version of the virus so that the body can produce antibodies that would fight off the virus, thus giving immunity to a stronger version.
It is very fascinating because the vaccine, mRNA-1273, is based on mRNA protein sequence instead of introducing a “weak” version of the virus to the body. Typically mRNA is made from a promoter being turned on so the genes have the instructions to make mRNA. I read that they used part of the genome of the virus to come up with this mRNA sequence.
The Coronavirus has a special type of attachment and entry that we haven’t seen before. The outer part of the virus is coated with protein “Spikes”. The goal of this vaccine is to introduce our bodies to this type of binding so we can produce the right antibodies.
Viruses have two reproductive cycles. Lysogenic and lytic cycles. Basically a virus hijacks a cell so that the Host is used to replicates the Virus since the virus can’t do it by itself. I am trying to research more into this topic but apparently the COVID virus has a unique way of replicating.
Key Words and Side Notes
Promoter: The switch that turns a gene on or off.
Transcription Factor: A protein that binds to a promoter to turn it on or off.
RNA Polyermase: An enzyme that aids the process of transcription.
Transcription: When a promoter is turned on so that genetic instructions are followed to produce mRNA
Translation: When mRNA is translated by tRNA (and rRNA) for protein synthesis.
mRNA= Messenger RNA
tRNA= Transfer RNA
rRNA= Ribosomal RNA
Genetics vary depending if the cells are Eukaryotic (animal) or Prokaryotic (Bacteria)
A promotor can also be turned on by MicroRNA, or DNA Methylation. Sometimes temperature and other conditions can also play a role if a promoter will be turned on or off because the transcription factor (a protein) can be denatured at certain temperatures.
I tried to explain this in an introductory way but there is always more to learn about this topic. I may have left out some things and please let me know if something doesn’t make sense.March 18, 2020 at 2:47 pm #343990
Thank you so much for the information you provided, I appreciate it!
I want to read it tomorrow morning when I feel more fresh and focused. I will incorporate it into my new thread about the coronavirus which I started earlier today. I will incorporate the information you provided into my thread sometime along the way, not necessarily tomorrow.
I may respond shortly to this or that thread later today, but will be back to your thread in about 16 hours from now.
anitaMarch 18, 2020 at 7:19 pm #344044
Anytime! I hope it is relevant information that is helpful to you and Kudos for starting the COVID thread. I hope you feel well rested for the coming days 🙂
I went to my doctor’s appointment and was prescribed gabapentin in addition to Lamictal. They are both anti-convulsants.
She said it would help me become a lot calmer and also help stabilize moods. I told her I smoked weed to try to combat my extra anxiety and this was her solution. She said that many people have told her that they feel a similar effect with gabapentin as they do with cannabis. So I am planning to quit for real this time. I can’t help but feel that in some ways I am not reaching my full potential with cannabis (in regards to memory) and I want to find out. I am also nervous to just try something new but it seems like a better option for treating anxiety than other types of prescriptions.
I am still going to make masks for fun. Design little space needles or something fun. Could be used for other purposes like to block out pollution or if a forest fire happens again. I don’t know but I think having something brightly colorful and positive during a weird time might lighten the mood.
March 18, 2020 at 7:42 pm #344050
- This reply was modified 3 weeks, 1 day ago by Zeeza.
I hope you find the best combination of meds that will work for you. Maybe some day you won’t take any. Good that you told the doctor about cannabis, glad you did. Masks for fun sounds good to me. Aren’t these weird times, it is downing on me how weird this is, this world wide pandemic. Let’s survive it together, come out better on the other side of this.
anitaMarch 18, 2020 at 7:48 pm #344052
I would hope that one day I won’t take anything. I have been against taking anything for so long but I want to be open to new things.
Absolutely! We will survive this all together as a global community. I read somewhere that homeless people are receiving more help throughout all of this. I hope through all of this weirdness we learn how to support each other and know that we are all in this together 🙂
ZeezaMarch 18, 2020 at 7:58 pm #344060
Together in bad times and good times, responsible to ourselves and to others, personally and socially responsible. This means that it is important that you never hate yourself again, that is, never act against yourself. This is no less important than not acting against other. I will be back to the computer tomorrow morning at about 6 or 7 (we are in the same time zone and State, amazing!)
anitaMarch 19, 2020 at 2:26 pm #344192
Thank you for reminding me how important it is to not act against myself just as I would with others. I care so much and I hope to transfer some of that to self care as well.
I woke up with a sore throat and a headache. I didn’t pick up my prescription yet and I thought maybe I have a sore throat and a dry cough from smoking. I wasn’t sure. But because I had a headache I thought it might be a good idea to take my temperature. I couldn’t find a thermometer at the store and work was expecting me. I told them what I was experiencing and they said please stay home if you aren’t feeling well. I wanted to take my temperature to verify if I was having an illness related symptoms or just a regular sore throat from irritants or a headache from stress.
I also had a fear of what if I was sick and I am going to spread this to people at work. I am sure I’ll be fine but what if the older people there get sick.
To try to verify if this fear is valid I called my doctor’s office and described what was going on and that I don’t know if I have a fever but I feel warm. I was referred to a walk in clinic.
At the entry of the clinic two workers interviewed me with a lot of personal protection gear on. I explained to them what was going on and that I just wanted to make sure I was safe to be around other people.
They asked for my number and my car info and asked me to wait in my car and the doctor would call me. He called me and asked more questions and he said because I wasn’t exposed go any known cases of the virus that I won’t be tested for that. He asked me to pull my car took my through this drive thru area. He had a face shield and everything. He took my temperature and it was only 99. Not really a fever at all after all of that. He still gave me a note saying to stay home for 72 hours after a fever subsides and if my symptoms improve (sore throat and headache).
I gave work this note and they are very understanding but I am just confused. Part of feels like if I just went to work maybe everything would of been fine. Another part of me is like if I am sick and my symptoms become worse best not to infect others. I don’t know. I feel like I might of made a mountain out of a mole hill. I apologize to work and said I just wanted to be safe than sorry and they appreciated that I took these steps.
I hope you are enjoying the sunshine and staying well 🙂 it is so much fun that we are in the similar time space.March 19, 2020 at 2:37 pm #344196
You did the right thing going to the walk in (more like a drive through) clinic and to stay away from work, basically self quarantining yourself for 72 hours. Better you do make “a mountain out of a mole hill” then infect someone and suffer terrible guilt over it. I am proud of you, if I may say so.
You mentioned smoking- you mean smoking cannabis or nicotine cigarettes, or both?